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KMID : 0525619970020040037
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1997 Volume.2 No. 4 p.37 ~ p.42
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The Effect of Calcium and Chitosan Metabolism to the Excretion of Radiostrontium in Mice
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김영호/Kim YH
범희승/김지열/노영복/Bom HS/Kim JY/Roh YB
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Abstract
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Chitosan, a natural nontoxic chelator, was reported to reduce whole body retention of radiostrontium in mice. As calcium has a similar chemical properties to strontium both of which be easily bound with hydroxyapatite structure, calcium can be either a competitor or enhancer to chitosan on the removal of radiostrontium. We compared the effect of chitosan and calcium on the excretion of ingested radioscrontium (85Sr). Chitosan or calcium(CaCl2) and usual food was mixed as 1:99 by weight. The mixed food to chitosan(group 1) or calcium (group 2) were given orally for 30 days before 85Sr administration. In other groups, mixed calcium and chitosan solution (group 3), 1% calcium (group 4), or 1% chitosan solution (group 5)was given for 7 days immediately after oral administration of 85SrCl2 (0.25 y Ci). In control group, no chitosan or calcium were given. Either chitosan or calcium was effective on the removal of 85Sr from mouse body(Table. 1). Addition of calcium on chitosan did not improve or deteriorate the effect of chitosan on the removal of 85Sr from mouse body. In conclusion, calcium was similarly effective on the removal of 85Sr from mouse body.
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